ceesdekker.net - An Overview
ceesdekker.net - An Overview
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‘Certainly, which is about ideal. I hunt for a Bodily knowledge of Organic systems within a base-up way. I think you may distinguish 3 strains of study in my group at the moment. The initial problems chromosome composition: How can you get yourself a metre-very long DNA polymer folded and organised in such a microscopic cell? We have now developed visualisation methods that let us to check how, as an example, SMC proteins loop DNA (movie on Youtube) so as to build up chromosomes.
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Around the similar time, the group of Paul McEuen, who was then centered for the University of California, Berkeley, confirmed related outcomes on ropes of bundled nanotubes. Based on the wrapping angle, nanotubes can are available in metallic or semiconducting variants, a prediction that we and Charles Lieber’s team at Harvard University independently verified employing scanning tunnelling spectroscopy experiments.
Deposition and atomic pressure microscopy of specific phthalocyanine polymers amongst nanofabricated electrodes
Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart style in 2005. (nl)
From the yrs adhering to these discoveries, my analysis interests shifted to biophysics and nanobiology, And that i turned considerably less associated with the development of nanotube electronics. The main target of numerous researchers in the sphere also shifted to graphene (wherever, funnily ample, the initial graphene ribbons were described as ‘nanotubes that are Slash open along their duration’) right after the discovery of The 2-dimensional materials in 2004.
We condition microorganisms into types that deviate from their all-natural phenotype. Particularly, I'll exhibit our capacity to shape live E. coli microbes into novel styles for example rectangles, squares, triangles and circles.
Atomic power microscopy demonstrates that vaccinia topoisomerase IB generates filaments on DNA inside of a cooperative style
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‘The fantastically delicate way through which factors in mother nature purpose never ever ceases to amaze me. If we remedy the puzzle of how lifestyle arrived into staying, I assume that my amazement on the complexity of creation should have enhanced and with it my awe for your greatness of the Creator.’
An built-in microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes
‘That worries the artificial cell, as Section of the Dutch BaSyC initiative. Craig Venter looked best-down in Those people days and determined about five hundred genes that happen to be minimally required for the performing cell. We want to glance https://www.ceesdekker.net bottom-up: how do we go from the few molecules to a whole Organic procedure?
2005, discovery in the system of DNA uncoiling by topoisomerase enzymes; discovery of lengthy-vary conformational adjustments in Mre11/DNA maintenance complexes; and initial pressure measurements on a DNA molecule within a nanopore
Eventually, I'll briefly sketch many of our Tips to check out the constructing of artificial cells, specially our initially ways to determine artificial mobile division.